Gireg Desmeulles, Vincent Ferec, Pascal Redou, Vincent Rodin and Alain-Claude Roudot.
A new PBTK modelling method based on multi-interaction paradigm.
FOODSIM'2010, Food Simulation Conference, pages 154-157, Braganca (Portugal), 24-26 June 2010.
Abstract:
One of the problems not clearly solved nowadays in food toxicology, is the evaluation of internal exposure to natural chemical contaminants. The worst solution is based on the concept that internal and external exposure are of the same level. One can go through this concept by considering biomarkers which can be used to calculate the inner contamination. Another solution is the use of a PBTK simulation method (Physiologically- Based Toxico-Kinetics). This method allows the knowledge of distribution of the contaminant over all the organs and their evolution in time. Unfortunately, the modeling and simulation processes are very hard to implement and use. The use of a technology issued from virtual modeling shows a good opportunity of developing a user interface easy to use for biologists. This interface is based on the multi interactions paradigm which is an evolution of the multi agent simulations.
Keywords: Exposure, Multi interactions modeling, Multi agent simulation, Toxicology, PBTK.
[link] [Desmeulles10a.pdf]

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