Gabriel Querrec, Vincent Rodin, Jean-François Abgrall,
Sébastien Kerdélo and J. Tisseau.
Use of Multiagents System for Simulation in Systems Biology.
BioMed 2003, IASTED International Conference on Biomedical Engineering,
pages 48-53, Salzburg (Austria), 25-27 June 2003.
Abstract:
Since emergence of molecular biology, one has improved knowledge about
intracellular network controlling living cell. In parallel, advances in
mathematic and computer science allow to simulate such complex phenomena.
Moreover, most methods need a global resolution of the system which makes
it difficult to be created and modified. We propose, in this study,
a distributed approach by multiagent system, to simulate MAPK pathway.
Moreover, we are able to integrate this model in an agent-cell to implement
his behavior. We believe that multiagents systems are good candidates for
systems biology simulation. We give in this study an example of
"in virtuo" simulation, i.e. model perturbation during
its execution.
Keywords:
Multiagent, Systems biology, "in virtuo" simulation, MAPK pathway.
[url]
[Querrec03c.pdf]