Pascal Redou, Sébastien Kerdélo, Christophe Le Gal, Gabriel Querrec, Vincent Rodin, Jean-François Abgrall and Jacques Tisseau.
Reaction-agents: First mathematical validation of a multi-agent system for dynamical biochemical kinetics.
EPIA'05, 12th Portuguese Conference on Artificial Intelligence, Covilhã (Portugal), 5-8 December 2005. Published in Progress in Artificial Intelligence; Lecture Notes in Computer Science (LNAI), Springer, volume 3808, pages 156-166, December 2005.
Abstract:
In the context of multi-agent simulation of biological complex systems, we present a reaction-agent model for biological chemical kinetics that enables interaction with the simulation during the execution. In a chemical reactor with no spatial dimension - e.g. a cell -, a reaction-agent represents an autonomous chemical reaction between several reactants : it reads the concentration of reactants, adapts its reaction speed, and modifies consequently the concentration of reaction products. This approach, where the simulation engine makes agents intervene in a chaotic and asynchronous way, is an alternative to the classical model - which is not relevant when the limits conditions change - based on differential systems. We establish formal proofs of convergence for our reaction-agent methods, generally quadratic. We illustrate our model with an example about the extrinsic pathway of blood coagulation.
[doi:10.1007/11595014_16] [Redou05a.pdf]

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