Abdoulaye Sarr, Alexandra Fronville, Pascal Ballet and Vincent Rodin.
French flag tracking by morphogenetic simulation under developmental
constraints. - Short version -
CIBB 2013, 10th International Meeting on Computational Intelligence Methods
for Bioinformatics and Biostatistics, paper 66, 12 pages, Nice (France),
20-22 June 2013.
Abstract:
Below the influence of the mechanical cues and genetic expression, constraints
underlying the developmental process play a key role in forms emergence.
Theses constraints lead to cells differentiation and sometimes pinpoint the
directions of cells growth.
To better understand these phenomena, we present in this paper our work focused
primarily on a development of a mathematical model taking into account the
co-evolution of cellular dynamics with it’s environment.
To study the influence of the developmental constraints, we have developed
algorithms to make and explore a base of genomes in order to check conditions
under which specific genes are activated and some patterns emerge to achieve a
specific shape.
From our model, we found a genome that can generate the French flag.
With this French flag pattern and its genome starting, we addressed the
following question : is there another genome in the simulated base that
achieves the same shape, i.e. the French flag pattern ?
Keywords:
mathematical modelling, simulation of biological systems,
morphogenesis, multi-agent system, French flag problem.
[Sarr13a.pdf]