Abdoulaye Sarr, Alexandra Fronville, Pascal Ballet and Vincent Rodin.
French flag tracking by morphogenetic simulation under developmental
constraints. - Long version -
CIBB 2013, 10th International Meeting on Computational Intelligence Methods
for Bioinformatics and Biostatistics, Nice (France),
20-22 June 2013.
Revised Selected Paper published in Lecture Notes in Bioinformatics a subseries
of Lecture Notes in Computer Science (LNCS), Springer, volume 8452,
pages 90-106, July 2014.
Abstract:
Below the influence of the mechanical cues and genetic expression, constraints
underlying the developmental process play a key role in forms’ emergence.
Theses constraints lead to cells’ differentiation and sometimes determine the
directions of cells growth.
To better understand these phenomena, we present in this paper our work focused
primarily on a development of a mathematical model.
A one which takes into account the co-evolution of cellular dynamics with it’s
environment.
To study the influence of the developmental constraints, we have developed
algorithms to make and explore a base of genomes.
The purpose of this exploration is first to check conditions under which
specific genes are activated.
Then, this exploration allows us to follow the conditions of emergence of some
patterns that lead to a specific shape.
From our model, we found a genome that can generate the French flag.
With this French flag pattern and its genome starting, we addressed the
following question : is there another genome in the simulated base that
achieves the same shape, i.e. the French flag pattern ?
Keywords:
mathematical modelling, simulation of biological systems, morphogenesis,
multi-agent system, French flag problem.
[doi:10.1007/978-3-319-09042-9_7]
[Sarr14b.pdf]